yes,i've actually gone as high as the one i'm doing right now,in a 90 hatch....it's a 514 crate motor.uses a 1050 cfm Dominator
built several 351 based motors,including a 408. BIG nasty Comp Cam in it,Roush 200 heads,10.5:1 compression,little bit o juicemand a Victor intake.nice and peppy
anyhoo,as far as jetting and everything goes it is STRICTLY on a what-do-you-have-now basis.you have to be able to say "i have THIS cam,THESE heads,THIS intake,This trans,This gear,in THIS car and i'm going to do THIS with it." then you say what carb to start with,but for any big-inch small bloch i'd start with a 750 vacuum on the street and a 750 DP for track use.chances are a SERIOUS motor will have a single plane intake--not great on the street,and not wise to use a vacuum secondary,so the double pumper would pretty much be a necessity.once you have the carb,you start with Holley's own baseline tune,say a 70 primary(front) jet and an 84 rear,.031 shooters,red accelerator pump cams.then you put it all together and get it running.
THEN comes the fun part.you get to spend a day at the track,or on a chassis dyno.you also get to spend on things like jets(a Holley assortment kit is a great idea),or a Holley/Percy's Adjust-A-Jet.lots of float bowl gaskets and o-rings too,cuz you'll be changing them out several times to get the front end tune proper.then do it AGAIN for the rears.in the meantime you'll also be fine tuning the accelerator pump system,with the pump cams and shooters,in order to get the crispest,bog free launch you can.once you're at the point where the car will not go faster,BINGO you've found happiness.of course,change anything else on the car or motor that affects engine performance and you get to fine tune it again
it sounds daunting,but it's really quite simple.pick up a book like "HOLLEY CARBS" by Dave Emmanuel,it's ancient but it tells everything you'll ever want to know aboot carbs and tuning.once you have a car tuned properly,the carb will work just as well as EFI for drivability,you'll get a few more HP at the expense (maybe) of some MPG.but you wont need a computer scientist and a laptop,a chip burner,a wide-band EGO,four sets of injectors....you get the idea