I am running the Tweecer RT. Great product but steep learning curve. Go to their website and it will direct you to a couple of forums. One is a yahoo type and one is like tweecer.oplink.com, (something) like that. Start reading, studying, and asking questions. There are informative posts and stickys to get you started. Try doing one thing, such as setting fans, and then go on to another until you get an idea of how it works.
After that just keep reading and learning, once you get the basics down and get an understanding of how our computers work it will start coming together. Now most of the stuff you won't need to touch or use so it seems a little more complicated than it actually is.
Just keep at it and have fun but be careful and use small steps, you'll get it. I have a pretty good handle on it and although I haven't mastered it compared to some, I can successfully do what ever tuning I need to do. I have had good luck and a lot of fun with it and think it is a great product, but you have to be willing to learn and most of the guys on those forums are more than willing to help.
When I took my car to the dyno the guys there were amazed at how right on my tune was just by SOTP testing and WB o2 that I use to tune the car. My fuel was dead on and we were able to put in about 2 degrees more timing (just to be safe w/ the SC setup), so I didn't leave much on the table. The shop owner said "It's guys like you that make me look bad when I can't tune another 20-30hp out of you combo bucause the tune is already right on.
Moral of the story, YOU CAN DO IT, it just takes time and it helps if it is fun to you. If it is something you don't really think you can handle or want to learn, you WILL NOT LIKE IT, a chip or tuning shop is a better alternative for you. GOOD LUCK!