I work for Ford and have a 2005 Escape V6 AWD has a winter beater. I get crappy mileage with mine lol. They are decent little suvs, like mine alot, drives really nice, AWESOME in the winter, and comfortable. Here are the issues with newer and older ones (before they turned into a fat Focus, the 2013+ is NOT an Escape to me).
4 speed tranny is horrible (2001-2008) most have the tranny blow up, mine blew up before I owned it under warranty (55000kms according to Ford History) have 110k on it now and still fine.
Brake lines crack (2001-2007 models) I replaced mine, but have seen many blow apart
Stab links wear fast on all models, replaced mine already, cheap and easy fix.
PTU seal leaks, more common on 09+ models and is something to look at before buying, very costly and time consuming repair, mine is sweating, I keep a close eye on it though
Left front axle seal leaks from 6 speed tranny (09+ models) there is a TSB out on this, it involves replacing the inner CV axle and seal of course
rear axle seal leaks on 2001-2007 escapes, expensive job, but can be done easily if you know how to manuever the rear diffy.
Front crank seals on all the 3.0L V6s tend to leak on them, replaced mine already, easy fix, took like 30-40 mins including jacking vehicle up.
Edges are nice vehicles too, suffer from the same PTU issues though. I was going to upgrade to an Edge in like 5 years but I need something that can tow more and the edge and escape are rated for the same capacity :/