It really depends on what heads and intake you plan on running. The problem with going with a higher lift cam and less duration is that boost just goes right out of your exhaust
Probably a stock pi intake and the stock npi heads. I'll also upgrade my MAF, cai, injectors, etc etc the typical stuff to run boost.
Orig shortblock can handle 350-375 rhwp no problems for a long time.
Once you go over 400 rwhp thats when your supposed to have trouble.
I ran 385 rwhp for over 2 yrs through my auto and now make 440 rwhp, no problems yet.
Then i should have no problem, since i'll be tuning it for around 350 rwhp.